Reviewed By
Overview
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
USERS' SCORE
Good
Based on 7 Reviews
8.5
Supplement Facts
Serving Size: 1 Tablet
Amount Per Serving
%DV
Vitamin B₆ (as Pyridoxal 5-Phosphate)
2.5 mg
147%
Folate (800 mcg as 6S)-5MTHF-Methyltetrahydrofolate Glucosamine Salt)
1,360 mcg DFE‡
340%
Vitamin B12 (as Methylcobalamin)
5,000 mcg
208,330%
Top Medical Research Studies
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
8
Vitamin B6 improves cholesterol and metabolism
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
7
We conducted a study to understand how vitamin B6 affects cholesterol levels in weaned piglets fed a high-protein diet. Our study involved eighteen piglets that were divided into three groups, each receiving different levels of vitamin B6: none, 4 mg/kg, and 7 mg/kg, over a period of 14 days.
While we did not find any significant overall changes in growth performance, we noticed that the group receiving 7 mg/kg of vitamin B6 had notably higher levels of total protein, cholesterol, and high-density lipoprotein in their blood. This suggests that higher vitamin B6 might positively influence cholesterol levels within specific contexts.
Although some improvements were found with vitamin B6 supplementation, it's important to note that we cannot definitively claim that it directly lowers cholesterol without further investigation. The study hints at a beneficial relationship, but the exact impact remains unclear when separated from the high-protein diet context.
Overall, our findings propose that adding vitamin B6 to diets might help with cholesterol management in weaned piglets, but more research is needed to fully understand these effects without the influence of other dietary components.
While we did not find any significant overall changes in growth performance, we noticed that the group receiving 7 mg/kg of vitamin B6 had notably higher levels of total protein, cholesterol, and high-density lipoprotein in their blood. This suggests that higher vitamin B6 might positively influence cholesterol levels within specific contexts.
Although some improvements were found with vitamin B6 supplementation, it's important to note that we cannot definitively claim that it directly lowers cholesterol without further investigation. The study hints at a beneficial relationship, but the exact impact remains unclear when separated from the high-protein diet context.
Overall, our findings propose that adding vitamin B6 to diets might help with cholesterol management in weaned piglets, but more research is needed to fully understand these effects without the influence of other dietary components.
Read More
Most Useful Reviews
9
Successful pregnancy
5 people found this helpful
Guaranteed to lower homocysteine! It helped facilitate my long-awaited second pregnancy. After one month, my homocysteine levels decreased, leading to pregnancy. Previously, I took regular folic acid. Now, I always keep it in my first aid kit and buy it for my parents, as high cholesterol can cause vascular issues. It comes in chewable tablets with a pleasant cherry flavour.
Read More
10
Effective treatment
1 people found this helpful
My homocysteine was 9.6 before starting this, and now it's 5, just what I aimed for! In functional and integrative medicine, it is understood that homocysteine should remain strictly between 5 and 7.5 to keep arteries and veins free of inflammation related to high cholesterol.
Read More
9
Normal homocysteine levels
1 people found this helpful
This remedy effectively neutralises the deficiency of folates and B12, preventing arterial and venous problems associated with high cholesterol. I take the homocysteine test annually after age 40 and bought this for my dad, whose level was 11. After the course, it returned to 6.
Read More
Medical Researches
SCIENTIFIC SCORE
Possibly Effective
Based on 9 Researches
7.7
- All Researches
9
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
Read More
9
Vitamin B6 reduces cholesterol levels
We aimed to understand how Vitamin B6 influences high cholesterol levels, particularly through its effects on lipid metabolism in rats induced by a high-fat diet. To set the stage for our exploration, we used male Sprague-Dawley rats and placed them on this fat-rich diet for two weeks to establish a hyperlipidemia model.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
We then supplied two groups of rats with varying doses of Vitamin B6—2.00 mg/kg and 3.00 mg/kg daily over the next eight weeks. Our findings shed light on Vitamin B6's potential to lower harmful Low-Density Lipoprotein Cholesterol (LDL-C) and overall blood cholesterol levels.
What's more, we observed significant reductions in triglycerides, atherogenic indexes, and various lipid ratios, while beneficial High-Density Lipoprotein Cholesterol (HDL-C) levels were elevated. The supplementation helped reduce fat accumulation in the liver and restored more normal heart and body weight ratios, highlighting its possible protective role against fat-related conditions.
Overall, our study suggests that Vitamin B6 could play an essential role in combating dyslipidemia and promoting better liver health through various mechanisms. These findings provide promising insights into a nutritional approach to managing high cholesterol and emphasize the importance of diet in health management.
Read More
9
Vitamin B6 improves cholesterol levels
In our study, we investigated how Vitamin B6 affects cholesterol levels in mice exposed to Myrin®-p Forte, an anti-tuberculosis drug known to cause liver damage. Mice were divided into different groups, with some receiving combinations of Myrin®-p Forte and Vitamin B6, while others were given only the drug or a control substance.
We observed that co-administering Vitamin B6 helped improve the overall lipid profile in the mice treated with Myrin®-p Forte. The results showed a significant reduction in levels of LDL, cholesterol, HDL, and triglycerides within this group. It appeared that Vitamin B6 worked synergistically with the leaves of Maytenus royleanus, which also offered protective benefits against the drug-induced liver injury.
However, while the study highlighted improvements in specific cholesterol levels when Vitamin B6 was included in treatment, we cannot state that Vitamin B6 alone had a significant independent effect on cholesterol management, as it was always combined with other treatments.
We observed that co-administering Vitamin B6 helped improve the overall lipid profile in the mice treated with Myrin®-p Forte. The results showed a significant reduction in levels of LDL, cholesterol, HDL, and triglycerides within this group. It appeared that Vitamin B6 worked synergistically with the leaves of Maytenus royleanus, which also offered protective benefits against the drug-induced liver injury.
However, while the study highlighted improvements in specific cholesterol levels when Vitamin B6 was included in treatment, we cannot state that Vitamin B6 alone had a significant independent effect on cholesterol management, as it was always combined with other treatments.
Read More
8
Vitamin B6 enhances growth and cholesterol
We assessed the impact of vitamin B6, or pyridoxine, on the growth and lipid metabolism of mandarin fish. By feeding these fish diets supplemented with various levels of pyridoxine over eight weeks, we aimed to see how this vitamin could help manage their cholesterol levels.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
Read More
8
Vitamin B6 improves cholesterol and metabolism
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
Read More
User Reviews
USERS' SCORE
Good
Based on 7 Reviews
8.5
- All Reviews
- Positive Reviews
- Negative Reviews
9
Successful pregnancy
5 people found this helpful
Guaranteed to lower homocysteine! It helped facilitate my long-awaited second pregnancy. After one month, my homocysteine levels decreased, leading to pregnancy. Previously, I took regular folic acid. Now, I always keep it in my first aid kit and buy it for my parents, as high cholesterol can cause vascular issues. It comes in chewable tablets with a pleasant cherry flavour.
Read More
10
Effective treatment
1 people found this helpful
My homocysteine was 9.6 before starting this, and now it's 5, just what I aimed for! In functional and integrative medicine, it is understood that homocysteine should remain strictly between 5 and 7.5 to keep arteries and veins free of inflammation related to high cholesterol.
Read More
9
Normal homocysteine levels
1 people found this helpful
This remedy effectively neutralises the deficiency of folates and B12, preventing arterial and venous problems associated with high cholesterol. I take the homocysteine test annually after age 40 and bought this for my dad, whose level was 11. After the course, it returned to 6.
Read More
9
Decreased homocysteine
I ordered this to lower homocysteine. After one month, it decreased from 12.20 to 8.95. My folic acid levels were at the upper limit, and I was hesitant to take vitamin B12 due to high dosage. I no longer take it, having switched to separate components.
Read More
9
Preventing strokes
4 people found this helpful
My husband takes this an hour after breakfast to reduce homocysteine levels. This supplement has an excellent combination of active folate and vitamin B12 in one pill. Using the sublingual form is best for B vitamins to avoid deposit on blood vessel walls, which can cause high cholesterol issues and lead to a stroke or heart attack.
Read More
Frequently Asked Questions
9
Successful pregnancy
5 people found this helpful
Guaranteed to lower homocysteine! It helped facilitate my long-awaited second pregnancy. After one month, my homocysteine levels decreased, leading to pregnancy. Previously, I took regular folic acid. Now, I always keep it in my first aid kit and buy it for my parents, as high cholesterol can cause vascular issues. It comes in chewable tablets with a pleasant cherry flavour.
9
Decreased homocysteine
I ordered this to lower homocysteine. After one month, it decreased from 12.20 to 8.95. My folic acid levels were at the upper limit, and I was hesitant to take vitamin B12 due to high dosage. I no longer take it, having switched to separate components.
10
Effective treatment
1 people found this helpful
My homocysteine was 9.6 before starting this, and now it's 5, just what I aimed for! In functional and integrative medicine, it is understood that homocysteine should remain strictly between 5 and 7.5 to keep arteries and veins free of inflammation related to high cholesterol.
7.5
Elderly father's remedy
3 people found this helpful
I purchased this for my elderly father, who has high cholesterol and issues with blood clots. He enjoys the candy-like taste, and it didn’t cause negative reactions despite his liver problems. The dosage is good with active folate, and since it needs to be absorbed, it aids in better assimilation of the vitamin complex. I will order more.
9
Normal homocysteine levels
1 people found this helpful
This remedy effectively neutralises the deficiency of folates and B12, preventing arterial and venous problems associated with high cholesterol. I take the homocysteine test annually after age 40 and bought this for my dad, whose level was 11. After the course, it returned to 6.
6
Good product quality
4 people found this helpful
I bought this as prescribed by my doctor for my husband, as he has high cholesterol. High levels lead to strokes and heart attacks. Many check cholesterol and assume that's the cause of their high blood pressure, but it's essential to check homocysteine levels instead. The quality is good, and the capsule size is small.
8
Vitamin B6 improves cholesterol and metabolism
We conducted a randomized clinical trial to investigate how pyridoxine hydrochloride (vitamin B6) affects high cholesterol levels and other metabolic factors in obese and overweight women. The study involved 44 women aged between 18 and 50. They were divided into two groups—one received 80 mg of vitamin B6 for eight weeks, while the other group was given a placebo.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
After the intervention, we observed some significant results. In the group receiving the vitamin B6, not only did total cholesterol levels decrease, but several other important markers showed improvement as well, including triglycerides and insulin resistance. Specifically, triglycerides saw a notable reduction with a p-value of less than 0.001, indicating strong statistical significance.
Overall, our findings suggest that vitamin B6 supplementation can positively influence cholesterol levels and improve body composition among women dealing with obesity. However, while the overall effects look promising for metabolic health, the study underscores the need for further investigation into the specific mechanisms at play.
9
We explored the connection between Pyridoxal 5'-Phosphate (PLP), a form of Vitamin B6, and cholesterol levels by analyzing data from over 6,400 adults. Our primary focus was to understand how PLP affects low-density lipoprotein cholesterol (LDL-C) and high-density lipoprotein cholesterol (HDL-C).
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
The results revealed some intriguing patterns. We found that as PLP levels increased, LDL-C levels tended to decrease significantly—by about 17.7% for every one-unit increase in PLP. In contrast, higher PLP levels were also associated with an increase in HDL-C, demonstrating a 1.95 times greater likelihood of achieving high HDL-C levels with rising PLP concentrations.
Notably, these effects were more pronounced in particular groups, such as diabetic patients and those who don't consume alcohol. However, while the study suggests potential benefits of PLP supplementation, it's important to remember that it didn't isolate PLP's effects from other influencing factors, so we can't claim that these outcomes are exclusively due to Vitamin B6.
Overall, our findings may highlight a new avenue for nutritional approaches to managing cholesterol and preventing cardiovascular issues, but additional research is needed to fully understand the implications.
4
We set out to investigate how vitamin B6 influences cholesterol levels, particularly focusing on its potential effects on high cholesterol. This research involved 360 healthy women who visited the nutrition clinic at Shohadaye Tajrish hospital in Tehran. We assessed their dietary habits, physical activity levels, and collected blood samples to measure their serum lipid levels.
Our findings revealed a noteworthy trend: higher levels of vitamin B6 were positively associated with increased triglycerides, raising some concerns about its impact on cholesterol levels. Despite this, we didn’t find significant benefits of vitamin B6 in reducing high cholesterol directly. The results suggest that while vitamin B6 plays a role, its effects may not be as beneficial as hoped regarding cholesterol management.
Overall, the relationship between vitamin B6 and cholesterol levels is complex, and further research is essential to fully understand these connections and their implications for dietary recommendations.
Our findings revealed a noteworthy trend: higher levels of vitamin B6 were positively associated with increased triglycerides, raising some concerns about its impact on cholesterol levels. Despite this, we didn’t find significant benefits of vitamin B6 in reducing high cholesterol directly. The results suggest that while vitamin B6 plays a role, its effects may not be as beneficial as hoped regarding cholesterol management.
Overall, the relationship between vitamin B6 and cholesterol levels is complex, and further research is essential to fully understand these connections and their implications for dietary recommendations.
8
Vitamin B6 enhances growth and cholesterol
We assessed the impact of vitamin B6, or pyridoxine, on the growth and lipid metabolism of mandarin fish. By feeding these fish diets supplemented with various levels of pyridoxine over eight weeks, we aimed to see how this vitamin could help manage their cholesterol levels.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
Our results were quite revealing. Fish that received a diet with 6.57 mg/kg of pyridoxine showed significant improvements. Notably, we saw an increase in weight gain and a better protein efficiency ratio, indicating that they were growing more efficiently. Importantly, the levels of beneficial cholesterol fractions, such as high-density lipoprotein (HDL), also increased, suggesting a positive influence on cholesterol management.
Additionally, we noted a drop in other metabolic markers, including serum glucose, which is related to energy processing within the body. Furthermore, the study indicated that the fish processed proteins and fats more efficiently, correlating with the upregulation of certain genes associated with lipid oxidation and synthesis.
Overall, our findings highlight that vitamin B6 plays a crucial role not only in promoting growth but also in potentially improving cholesterol profiles in aquatic species like the mandarin fish. We concluded that the optimal dietary requirement for pyridoxine to achieve these benefits lies between 6.17 to 6.41 mg/kg.
References
- Zhang RY, Chen Y, Yan XQ, Zhang Y, Zhou H, et al. Association of pyridoxal 5'-phosphate (PLP) with lipid profiles: a population-based cohort study. Front Nutr. 2025;12:1545301. 10.3389/fnut.2025.1545301
- Xie RP, Liang XF, Peng D, Zhang QW, Wu DL, et al. Dietary supplementation of pyridoxine can enhance the growth performance and improve the protein, lipid utilization efficiency of mandarin fish (Siniperca chuatsi). Fish Physiol Biochem. 2023;49:1063. 10.1007/s10695-023-01223-3
- Abbas Torki S, Bahadori E, Shekari S, Fathi S, Gholamalizadeh M, et al. Association between the index of nutritional quality and lipid profile in adult women. Endocrinol Diabetes Metab. 2022;5:e358. 10.1002/edm2.358
- Haidari F, Mohammadshahi M, Zarei M, Haghighizadeh MH, Mirzaee F. The Effect of Pyridoxine Hydrochloride Supplementation on Leptin, Adiponectin, Glycemic Indices, and Anthropometric Indices in Obese and Overweight Women. Clin Nutr Res. 2021;10:230. 10.7762/cnr.2021.10.3.230
- Zhang Q, Zhang DL, Zhou XL, Li Q, He N, et al. Antihyperlipidemic and Hepatoprotective Properties of Vitamin B6 Supplementation in Rats with High-Fat Diet-Induced Hyperlipidemia. Endocr Metab Immune Disord Drug Targets. 2021;21:2260. 10.2174/1871530321666210809152555
- Shabbir M, Afsar T, Razak S, Almajwal A, Khan MR. Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice. Lipids Health Dis. 2020;19:46. 10.1186/s12944-020-01231-9
- Li J, Yin L, Wang L, Li J, Huang P, et al. Effects of vitamin B6 on growth, diarrhea rate, intestinal morphology, function, and inflammatory factors expression in a high-protein diet fed to weaned piglets1. J Anim Sci. 2019;97:4865. 10.1093/jas/skz338
- Garoufi A, Papadaki M, Kalogiannis M, Zerva U, Charakida M, et al. Beneficial Effects of a Nutraceutical Combination on Lipid Profiles in Children with Moderate and Severe Hypercholesterolemia. Biomolecules. 2024;14. 10.3390/biom14121608
- Qi J, Wu H, Chen H, Han W. Genetically predicted lipid traits mediate the association between folic acid and atherosclerosis. Sci Rep. 2024;14:19052. 10.1038/s41598-024-69728-2
